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Mycoplasma pneumonia
Blood methods
Mycoplasma pneumoniaMycoplasma pneumoniae is a small bacterium that primarily causes respiratory tract infections. M. pneumoniae lacks a cell wall, distinguishing it from many other bacteria and making it naturally resistant to antibiotics that target cell wall synthesis, such as penicillin. Transmission of M. pneumoniae occurs through respiratory droplets during close contact between humans and infections commonly occur in group settings, most often in children or young adults. While M. pneumoniae infections primarily affect the upper respiratory tract, they can sometimes progress to pneumonia. M. pneumoniae pneumonia is often referred to as atypical pneumonia, as its clinical and radiological presentation differ from typical community-acquired pneumonia caused by bacteria, such as Streptococcus pneumoniae. Symptoms develop gradually and may include a persistent dry cough, sore throat, hoarseness, headache, fever, and fatigue. M. pneumoniae infections tend to occur in cyclical outbreaks, typically every 3 to 7 years, with very few cases between outbreaks. Diagnosis of M. pneumoniae infection is typically made by detecting specific DNA in respiratory tract secretions or by identifying specific antibodies in the blood. M. pneumoniae pneumonia is treated with specific antibiotics, including macrolides, fluoroquinolones, and tetracyclins. Compared to S. pneumoniae pneumonia, M. pneumoniae pneumonia is most often a mild disease that does not require hospitalization. Differential abundance analysisThis section presents the disease-specific results of the differential abundance analyses. The analyses are reported for three comparisons: 1) disease vs. all other diseases, 2) disease vs. diseases from the same class, and 3) disease vs. healthy samples. Disease vs All other
Disease vs Class
Disease vs Healthy
Figure 1: In the volcano plot, proteins are plotted based on their fold change (logFC) on the x-axis and the statistical significance of the change (-log10 adjusted p-value) on the y-axis. Proteins considered differentially abundant are highlighted, defined by an adjusted p-value < 0.05 and an absolute logFC > 0.5.
Table 1: The summary table lists the results for all comparisons, sorted by p-value by default. It includes key metrics such as fold change and adjusted p-value, to allow exploration of the most significant proteins for each comparison.
Figure 1: In the volcano plot, proteins are plotted based on their fold change (logFC) on the x-axis and the statistical significance of the change (-log10 adjusted p-value) on the y-axis. Proteins considered differentially abundant are highlighted, defined by an adjusted p-value < 0.05 and an absolute logFC > 0.5.
Table 1: The summary table lists the results for all comparisons, sorted by p-value by default. It includes key metrics such as fold change and adjusted p-value, to allow exploration of the most significant proteins for each comparison.
Figure 1: In the volcano plot, proteins are plotted based on their fold change (logFC) on the x-axis and the statistical significance of the change (-log10 adjusted p-value) on the y-axis. Proteins considered differentially abundant are highlighted, defined by an adjusted p-value < 0.05 and an absolute logFC > 0.5.
Table 1: The summary table lists the results for all comparisons, sorted by p-value by default. It includes key metrics such as fold change and adjusted p-value, to allow exploration of the most significant proteins for each comparison.
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