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Pediatric retinoblastoma
Blood methods
Pediatric retinoblastomaRetinoblastoma is a malignant tumor that arises in the developing retina of young children. It can occur in one or both eyes, with bilateral cases often linked to genetic factors. Typically, the tumor is diagnosed before the age of three, as parents may observe differences in the child's pupils or signs of leukocoria (a white reflection in the pupil) or strabismus (crossed eyes). The treatment approach for retinoblastoma varies based on the tumor's size and stage. Common modalities include chemotherapy, radiation therapy, and in some cases surgical intervention. The prognosis is generally favorable, with high survival rates; most children retain good vision in at least one eye. Differential abundance analysisThis section presents the disease-specific results of the differential abundance analyses. The analyses are reported for three comparisons: 1) disease vs. all other diseases, 2) disease vs. diseases from the same class, and 3) disease vs. healthy samples. Disease vs All other
Disease vs Class
Disease vs Healthy
Figure 1: In the volcano plot, proteins are plotted based on their fold change (logFC) on the x-axis and the statistical significance of the change (-log10 adjusted p-value) on the y-axis. Proteins considered differentially abundant are highlighted, defined by an adjusted p-value < 0.05 and an absolute logFC > 0.5.
Table 1: The summary table lists the results for all comparisons, sorted by p-value by default. It includes key metrics such as fold change and adjusted p-value, to allow exploration of the most significant proteins for each comparison.
Figure 1: In the volcano plot, proteins are plotted based on their fold change (logFC) on the x-axis and the statistical significance of the change (-log10 adjusted p-value) on the y-axis. Proteins considered differentially abundant are highlighted, defined by an adjusted p-value < 0.05 and an absolute logFC > 0.5.
Table 1: The summary table lists the results for all comparisons, sorted by p-value by default. It includes key metrics such as fold change and adjusted p-value, to allow exploration of the most significant proteins for each comparison.
Figure 1: In the volcano plot, proteins are plotted based on their fold change (logFC) on the x-axis and the statistical significance of the change (-log10 adjusted p-value) on the y-axis. Proteins considered differentially abundant are highlighted, defined by an adjusted p-value < 0.05 and an absolute logFC > 0.5.
Table 1: The summary table lists the results for all comparisons, sorted by p-value by default. It includes key metrics such as fold change and adjusted p-value, to allow exploration of the most significant proteins for each comparison.
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The Human Protein Atlas
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